09:00 – 09:30 Opening ceremony and welcome addresses Emiliana Konova, Elissaveta Naumova, Dobroslav Kyurkchiev
Opening Session: “The Mosaic of Autoimmunity” Chairpersons: Yehuda Shoenfeld and Elissaveta Naumova
Plenary lectures
09:30 – 09:50 The Mosaic of autoimmunity: the importance of the microbiome Yehuda Shoenfeld
09:50 – 10:10 Autoimmunity and Primary Immune Deficiency Elissaveta Naumova
10:10 – 10:30 Autoimmunity in Hereditary angioedema Marianna Murdjeva
10:30 – 10:50 Tregs in the immune-endocrine network Velislava Terzieva
10:50 – 11:30 Discussion
11:30 – 12:00 Coffee Break and visit the Exhibition
Session 2: “The Diagnostic Methods in Autoimmunity: Resolved and Unresolved Issues”
Chairpersons: Dobroslav Kyurkchiev and Ekaterina Ivanova-Todorova
Plenary lectures
12:00 – 12:20 Antinuclear antibodies – not only autoimmunity Dobroslav Kyurkchiev
12:20 – 12:40 The bumpy journey to early diagnosis of systemic sclerosis - fundamentals, present and future perspectives Ekaterina Krassimirova
12:40 – 13:00 The clinical impact of both classic and novel autoantibodies in the diagnosis of Idiopathic Inflammatory Myopathies (IIMs) Hristina Andreeva and Gunnstein Bakland
13:00 – 14:00 Lunch Break
Short Oral Presentations
14:00 – 14:10 Clinical and immunological phenomena in first degree relatives of patients with SLE, PSS and SS. Bogdan Penev, Ekaterina Ivanova-Todorova, Ekaterina Krasimirova, Kalina Tumangelova-Yuzeir, Georgi Vasilev, Simeon Monov, Dobroslav Kyurkchiev
14:10 – 14:20 Immunofluorescent images of anti-Ro-52 antibodies in different autoimmune disorders Kalina Tumangelova-Yuzeir
14:20 – 14:30 Anti-carbamylated protein antibodies in Bulgarian patients with Rheumatoid arthritis Petya Gardjeva, Nedyalka Staykova, Mariya Ivanovska, Eleonora Hristova, Marianna Murdjeva
14:30 – 14:40 Cytokine mRNA and Protein Levels in Systemic Sclerosis Valentin Dichev, Rositsa Karalilova, Nikolay Mehterov, Maria Kazakova, Anastas Batalov, Marco Matucci-Cerinic,Victoria Sarafian
14:40 – 14:50 Autoimmune response against complement proteins in plasma Galya Mihaylova, Vasil Vasilev, Desislava Ivanova, Marie Daugan, Remi Noe, Marie-Agnes Dragon-Durey, Lubka Roumenina, Maria Radanova
14:50 – 15:00 Short Company Presentation
15:00 – 15:30 Discussion
15:30 – 16:00 Coffee Break and visit the Exhibition
Session 3: “The Animal models: Good or Bad News for Autoimmunity?” Chairpersons: Andrey Tchorbanov and Nikolina Mihaylova
Plenary lectures
16:00 – 16:20 Progression of autoimmunity and failure of reproduction – lessons from the animal models Andrey Tchorbanov
Short oral presentations
16:20 – 16:30 B and T cell engagement during systemic lupus erythematosus development Nikolina Mihaylova
16:30 – 16:40 Methyl supplemented diet delays the onset of lupus like disease in autoimmune MRL mice Kalina Nikolova-Ganeva
16:40 – 16:50 Protein-engineered molecules carrying GAD65 epitopes and targeting CR1 selectively down-modulate disease-associated human B lymphocytes. Iliyan Manoylov, Gabriela Boneva, Irini Doytchinova, Nikolina Mihaylova, Andrey Tchorbanov
16:50 – 17:30 Discussion
19:00 Concert and Official Diner, Hotel “Balkan”
Session 4: “The Treatment of Autoimmune diseases: The Good News in 2019” Chairpersons: Lyubomir Marintchev and Emiliana Konova
Plenary lectures
09:00 – 09:20 Contemporary view for the treatment of autoimmune rheumatic diseases with biologics Lyubomir Marintchev
09:40 – 10:00 The impact of IVIG on pregnancy success rate in ART: a 10-year experience Emiliana Konova
Short Oral Presentations
10:00 – 10:10 Assessment of clinically relevant autoantibodies in IVIG preparations
Svetla Blazheva, Emiliana Konova, Valentina Petkova, Dobroslav Kyurkchiev, Ekaterina Todorova-Ivanova, Bogdan Penev
10:10 – 10:20 Secretory factors present in AT-MSC conditioned medium exert immunosuppressive effect on T helper cells in rheumatoid arthritis in vitro. Georgi Vasilev
10:20 – 10:30 Effect of IFNγ on mesenchymal stem cells Kalina Belemesova
10:30 – 10:40 Dynamics in some immunological parameters in patients with ANCA vasculitides treated with Rituximab vs. conventional therapy Adelina Yordanova
10:40 – 10:50 Altered Th17-related Cytokine Profile in Rheumatoid Arthritis after
Biological DMARDS Treatment Irena Manolova, Georgi Vasilev, Mariana Ivanova, Rumen Stoilov, Spaska Stanilova, Lyuba Miteva
10:50 – 11:00 Discussion
11:00 – 11:30 Coffee Break and visit of Exhibition
Session 5: “Nutrition, Drugs and Autoimmunity”
Chairpersons: Yehuda Shoenfeld and Dobroslav Kyurkchiev
Plenary lectures
11:30 – 11:50 Cannabis and autoimmunity: the new avenue Bat Sheva Porat
11:50 – 12:10 Can diet prevent or ameliorate autoimmune diseases Yehuda Shoenfeld
12:10 – 12:30 Food intolerance and autoimmunity Ekaterina Ivanova-Todorova
12:30 – 12:40 Food intolerance of IgG type against 24 food antigens in patients with irritable bowel syndrome (IBS) Iskra Altankova, Tsvetelina Velikova, Victoria Georgieva, Alexander Kukov, Milena Peruhova, Nona Yurukova, Antoaneta Mihova, Tsanka Mehandzhiyska-Marinova, Galina Mizgova, Velislava Tersieva, Galina Zhelezova
12:40 – 13:00 Time to rekindle the clinical focus on drug-induced autoimmune reactions Diana Pendicheva
13:00 – 13:20 Advances in Homeopathy and Immunology - clinical research, recent concepts and practical advices Nonna Petrova
13:20 – 13:30 Discussion
13:30 – 14:30 Lunch Break
Session 6: “Chronic Fatigue Syndrome and Varia”
Chairpersons: Maria Nikolova and Iskra Altankova
Plenary lectures
14:30 – 14:50 CFS and the ASIA syndrome: pathogenesis and autoimmunity Yehuda Shoenfeld
Short Oral presentations, Case reports and Posters
15:20 – 15:30 Immune profiling of patients with "chronic fatigue syndrome" - the questions to answer Maria Nikolova, Radoslava Emilova, Yana Todorova
15:30 – 15:40 Human Herpesvirus Infections and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evelina Shikova, Valentina Reshkova, Аntoniya Kumanova1 Sevdalina Raleva
15:40 – 15:50 Autoimmune features in SCID patient with hypomorphic RAG mutation;
Spaska Lesichkova, Snezhina Mihaylova, Nevena Gesheva, Petya Yankova, Marta Baleva, Elissaveta Naumova
15:50 – 16:00 Severe disturbance in sperm parameters in autoimmune thyroid disease Sava Petrov, Danail Martinov, Nina Ayvazova, Emiliana Konova
16:00 – 16:10 Rheumatoid arthritis and diabetes mellitus - benefits of biologic therapy: a case report Simeon Petkov, Sarita Kostova, Martin Nikolov, Nikolay Nikolov, Tzvetan Lukanov
16:10 – 16:20 General principles of the biological therapy in autoimmune and inflammatory joint diseases in rheumatology practice Martin Nikolov, Borislava Zhelezarova, Simeon Petkov, Svetla Blazheva, Nikolay Nikolov, Tzvetan Lukanov
16:20 – 16:30 Changes of CD161 positive T cells subsets in patients with Hashimoto’s thyroiditis Emil Slavov, Julieta Gerenova, Krasimira Nancheva
16:30 – 16:40 Discussion
16:40 – 17:00 Coffee Break
Session 7: “Patients and doctors”
Chairpersons: Boryana Boteva and Penka Georgieva (Working language - Bulgarian)
17:00 – 18:00 Discussion and presentations:
Anelia Rangelova, Psychotherapist
Petio Chakarov, Lawyer
Boryana Boteva, President of Bulgarian organization for people with rheumatic diseases
18:00 – 18:30 Closing Ceremony
20:00 Dinner
09:00 – 12:00 Meeting of the members of the Expert committee of the Bulgarian
Association of Clinical Immunology – Hotel “Balkan”
